Relationship between oestrogen-receptor content and histological grade in human primary breast tumours

A series of 300 patients presenting consecutively with primary operable breast cancer has been studied. A significant correlation was found between oestrogen-receptor (ER) content and histological grade: the better-differentiated tumours rarely lacked receptor. This correlation was significant only...

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Veröffentlicht in:	British journal of cancer 1978-12, Vol.38 (6), p.745-748
Hauptverfasser:	Maynard, P V, Davies, C J, Blamey, R W, Elston, C W, Johnson, J, Griffiths, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomedical and Life Sciences Biomedicine Bone Neoplasms Breast Neoplasms - analysis Breast Neoplasms - pathology Cancer Research Cell Transformation, Neoplastic Drug Resistance Epidemiology Female Humans Lung Neoplasms Lymph Nodes - pathology Mastectomy Menopause Middle Aged Molecular Medicine Neoplasm Metastasis Neoplasm Recurrence, Local Oncology original-article Prognosis Receptors, Estrogen - analysis
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Beschreibung
Zusammenfassung:	A series of 300 patients presenting consecutively with primary operable breast cancer has been studied. A significant correlation was found between oestrogen-receptor (ER) content and histological grade: the better-differentiated tumours rarely lacked receptor. This correlation was significant only in women defined as post-menopausal. Data on early recurrence of disease indicate a worse prognosis for women in whom primary tumours are ER-.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.1978.282