Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects

Aims To assess the effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem. Methods In a randomized cross‐over study with two phases, 10 healthy subjects ingested 10 mg of zolpidem with or without oral voriconazole pretreatment. The concentrations of zolpidem were measured in plasma up to 24 h and pharmacodynamic variables were monitored for 12 h. Results Voriconazole increased the peak plasma concentration of zolpidem by 1.23‐fold [P