The IL23 axis plays a key role in the pathogenesis of IBD

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal infl...

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Veröffentlicht in:	Gut 2007-10, Vol.56 (10), p.1333-1336
Hauptverfasser:	McGovern, Dermot, Powrie, Fiona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial infections Biological and medical sciences Crohn's disease Cytokines dendritic cell Dendritic cells Gastroenterology. Liver. Pancreas. Abdomen Genetic Predisposition to Disease Growth factors Humans IBD IFNγ IL23R Immune system Inflammation Inflammatory bowel disease Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - therapy interferon γ interleukin interleukin 23 receptor Interleukin-12 - genetics Interleukin-23 - genetics Interleukin-23 - immunology irritable bowel disease Leading Lymphocytes Medical sciences Mice Neutrophils Other diseases. Semiology Receptors, Interleukin - genetics Receptors, Interleukin - immunology Rodents single-nucleotide polymorphism Small intestine SNP Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Studies T helper TGFβ TNFα transforming growth factor β tumour necrosis factor α
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Beschreibung
Zusammenfassung:	Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.
ISSN:	0017-5749 1468-3288
DOI:	10.1136/gut.2006.115402