High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology

The Mouse Biomedical Informatics Research Network (MBIRN) has been established to integrate imaging studies of the mouse brain ranging from three-dimensional (3D) studies of the whole brain to focused regions at a sub-cellular scale. Magnetic resonance (MR) histology provides the entry point for man...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2007-08, Vol.37 (1), p.82-89
Hauptverfasser:	Johnson, G. Allan, Ali-Sharief, Anjum, Badea, Alexandra, Brandenburg, Jeffrey, Cofer, Gary, Fubara, Boma, Gewalt, Sally, Hedlund, Laurence W., Upchurch, Lucy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquisitions & mergers Animals Arrays Automation Autosegmentation Brain Brain - anatomy & histology Brain research Databases as Topic Dominance, Cerebral - physiology Histology Image Enhancement - methods Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional - methods Infrastructure Magnetic resonance histology Magnetic Resonance Imaging - methods Methods Mice Mice, Inbred C57BL Mouse Neurosciences Phenotype Rodents Sensitivity and Specificity Software Studies
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Beschreibung
Zusammenfassung:	The Mouse Biomedical Informatics Research Network (MBIRN) has been established to integrate imaging studies of the mouse brain ranging from three-dimensional (3D) studies of the whole brain to focused regions at a sub-cellular scale. Magnetic resonance (MR) histology provides the entry point for many morphologic comparisons of the whole brain. We describe a standardized protocol that allows acquisition of 3D MR histology (43-μm resolution) images of the fixed, stained mouse brain with acquisition times
ISSN:	1053-8119 1095-9572
DOI:	10.1016/j.neuroimage.2007.05.013