Biological and prognostic role of acid cysteine proteinase inhibitor (ACPI, cystatin A) in non-small-cell lung cancer

Background: Acid cysteine protease inhibitor (ACPI) is an intracellular protein, often linked to neoplastic changes in epithelium and thought to have an inhibitory role in malignant transformation. Aim: To analyse the expression and prognostic role of ACPI in non-small-cell lung cancer (NSCLC). Meth...

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Veröffentlicht in:	Journal of clinical pathology 2007-05, Vol.60 (5), p.515-519
Hauptverfasser:	Leinonen, T, Pirinen, R, Böhm, J, Johansson, R, Rinne, A, Weber, E, Kosma, V-M
Format:	Artikel
Sprache:	eng
Schlagworte:	acid cysteine protease inhibitor ACPI Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Large Cell - metabolism Carcinoma, Large Cell - pathology Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cystatins - metabolism Cysteine Proteinase Inhibitors - metabolism disease-free survival DSF Follow-Up Studies Humans Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical sciences Middle Aged Neoplasm Staging non-small-cell lung cancer NSCLC Original overall survival Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques PBS phosphate buffer solution Pneumology Precancerous Conditions - metabolism Prognosis Survival Analysis Tumors of the respiratory system and mediastinum
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Zusammenfassung:	Background: Acid cysteine protease inhibitor (ACPI) is an intracellular protein, often linked to neoplastic changes in epithelium and thought to have an inhibitory role in malignant transformation. Aim: To analyse the expression and prognostic role of ACPI in non-small-cell lung cancer (NSCLC). Method: Histological samples from 199 patients with resected NSCLC were stained immunohistochemically for the expression of ACPI in normal and preneoplastic bronchial epithelium, and in various types of lung carcinomas. Results: A normal bronchial epithelium showed positive staining for ACPI in the basal cells, whereas the upper two-thirds of the dysplastic epithelium was ACPI positive. High staining for ACPI was found in 74% (91/123) of squamous-cell carcinomas, whereas 16% (8/49) of adenocarcinomas and 30% of (8/27) large-cell carcinomas showed the high expression of ACPI (p
ISSN:	0021-9746 1472-4146
DOI:	10.1136/jcp.2006.038711