Disease progression and liver cancer in the ferroportin disease

In 2006, at the age of 83 years, hepatic ultrasound (US) examination of the proband identified two hyperechoic nodules in the liver; contrast-enhanced MRI scan confirmed the US examination findings and a US-guided liver biopsy documented a well-differentiated hepatocellular carcinoma (fig 1A), as shown by antihepatocyte antibody stain (not shown here), in the absence of cirrhosis. [...]the ferroportin disease may progress if not properly treated, and complicate with liver cancer even without cirrhosis, in the presence of cocarcinogenic factors, such as occult HBV infection.