Evaluation of the EIE-IgM-Leptospirose assay for the serodiagnosis of leptospirosis

Access to low-cost, effective diagnosis for leptospirosis is urgently needed in developing countries. The EIE-IgM-Leptospirose, a kit produced for public health laboratories in Brazil, was shown to have a sensitivity of 76% (77 of 102 patients) and 100% (102 of 102 patients) during acute and convale...

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Veröffentlicht in:	Acta tropica 2007-06, Vol.102 (3), p.206-211
Hauptverfasser:	McBride, Alan J.A., Pereira, Fernanda A., da Silva, Emilson D., de Matos, Rosan B., da Silva, Edimilson D., Ferreira, Antônio G.P., Reis, Mitermayer G., Ko, Albert I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Biological and medical sciences Brazil Brazil - epidemiology Copenhageni Diagnosis Enzyme-Linked Immunosorbent Assay Epidemics General aspects Human bacterial diseases Humans IgM ELISA Immunoglobulin M - analysis Infectious diseases Leptospira Leptospirosis Leptospirosis - diagnosis Leptospirosis - epidemiology Leptospirosis - immunology Medical sciences Miscellaneous Reagent Kits, Diagnostic Sensitivity and Specificity Serologic Tests Serovar Urban
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Beschreibung
Zusammenfassung:	Access to low-cost, effective diagnosis for leptospirosis is urgently needed in developing countries. The EIE-IgM-Leptospirose, a kit produced for public health laboratories in Brazil, was shown to have a sensitivity of 76% (77 of 102 patients) and 100% (102 of 102 patients) during acute and convalescent-phase leptospirosis, respectively, and a specificity of 93–100% (total healthy and patient control subjects evaluated, 486). These findings indicate that the assay will be useful for diagnosis of this emerging infectious disease in Brazil and other developing countries.
ISSN:	0001-706X 1873-6254
DOI:	10.1016/j.actatropica.2007.05.002