Wash‐out of noradrenaline and its metabolites by calcium‐free reperfusion after ischaemia: support for the concept of ischaemia‐induced noradrenaline release

Wash‐out of noradrenaline and its metabolites by calcium‐free reperfusion after ischaemia: support for the concept of ischaemia‐induced noradrenaline release

The outflow of noradrenaline (NA) and its metabolites on reperfusion after 60 min of regional ischaemia in the isolated heart of the rat was not diminished when calcium was omitted from the reperfusion medium. The findings suggest a release of NA during ischaemia, washed‐out at reperfusion.

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Bibliographische Detailangaben
Veröffentlicht in:British journal of pharmacology 1984-01, Vol.81 (1), p.22-24
Hauptverfasser: Abrahamsson, T., Almgren, O., Carlsson, L.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Calcium - physiology
Catecholaminergic system
Coronary Circulation
Glucose - metabolism
Lactates - metabolism
Lactic Acid
Male
Medical sciences
Myocardium - metabolism
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Norepinephrine - metabolism
Perfusion
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
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Beschreibung
Zusammenfassung:The outflow of noradrenaline (NA) and its metabolites on reperfusion after 60 min of regional ischaemia in the isolated heart of the rat was not diminished when calcium was omitted from the reperfusion medium. The findings suggest a release of NA during ischaemia, washed‐out at reperfusion.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1984.tb10738.x