Papillary Necrosis in Experimental Analgesic Nephropathy

Papillary Necrosis in Experimental Analgesic Nephropathy

A proprietary aspirin, phenacetin, and caffeine preparation given to rats in a dose equivalent to that taken by patients with analgesic nephropathy produced papillary necrosis in 55%. There was a higher incidence in rats deprived of fluids overnight. Papillary necrosis was not noted in rats receivin...

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Veröffentlicht in:BMJ 1969-01, Vol.1 (5637), p.161-162
Hauptverfasser: Saker, B. M., Kincaid-Smith, Priscilla
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics
Animal cannibalism
Animals
Aspirin
Autolysis
Caffeine
Dosage
Kidney Papillary Necrosis - chemically induced
Lesions
Necrosis
Papillae
Phenacetin
Preliminary Communications
Rats
Water Deprivation
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Zusammenfassung:A proprietary aspirin, phenacetin, and caffeine preparation given to rats in a dose equivalent to that taken by patients with analgesic nephropathy produced papillary necrosis in 55%. There was a higher incidence in rats deprived of fluids overnight. Papillary necrosis was not noted in rats receiving twice as much phenacetin. These findings support the argument that phenacetin should not be singled out as the substance responsible for analgesic nephropathy in man.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.1.5637.161