Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids

Lower pre-chemotherapy night time cortisol excretion predicted more severe cisplatin induced nausea and vomiting in 42 ovarian cancer patients receiving ondansetron as a single antiemetic agent. Dexamethasone administration added to the antiemetic effect of ondansetron principally in patients who ha...

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Veröffentlicht in:	British journal of cancer 1993-07, Vol.68 (1), p.112-114
Hauptverfasser:	HURSTI, T. J, FREDRIKSON, M, STEINECK, G, BÖRJESON, S, FÜRST, C. J, PETERSON, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antiemetics Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cisplatin - therapeutic use Dexamethasone - therapeutic use Doxorubicin - administration & dosage Drug toxicity and drugs side effects treatment Female Humans Hydrocortisone - physiology Medical sciences Melphalan - administration & dosage Middle Aged Ondansetron - therapeutic use Ovarian Neoplasms - drug therapy Pharmacology. Drug treatments Toxicity: digestive system
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Zusammenfassung:	Lower pre-chemotherapy night time cortisol excretion predicted more severe cisplatin induced nausea and vomiting in 42 ovarian cancer patients receiving ondansetron as a single antiemetic agent. Dexamethasone administration added to the antiemetic effect of ondansetron principally in patients who had low excretion of cortisol.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.1993.295