Abducens palsy and Sjögren’s syndrome induced by pegylated interferon therapy

The enhancement of the abducens nerve is seen in disseminated tumour, inflammation, trauma, venous congestion or autoimmune disease, but less likely in diabetic microinfarcts. 6 We assume that the IFN-activated immune system induced an acute inflammatory process in the abducens nerve, which appeared as the enhancement, and led to ensuing development of SS. [...]IFNs have complex immunomodulating effects and frequently induce or exacerbate autoimmune disease. 7, 8 The symptom resolved spontaneously as abducens palsy usually does.