THE EFFECT OF SULFINPYRAZONE (ANTURAN) ON PLATELET ECONOMY AND BLOOD COAGULATION IN MAN

THE EFFECT OF SULFINPYRAZONE (ANTURAN) ON PLATELET ECONOMY AND BLOOD COAGULATION IN MAN

Sulfinpyrazone (Anturan) administered in therapeutic doses over a period of several weeks produced prolongation of platelet survival and reduced turnover but with little change in blood coagulation. The changes in platelet survival and turnover were associated with reduced platelet adhesiveness. It...

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Veröffentlicht in:Canadian Medical Association journal 1965-04, Vol.92 (15), p.818-821
Hauptverfasser: SMYTHE, H A, OGRYZLO, M A, MURPHY, E A, MUSTARD, J F
Format: Artikel
Sprache:eng
Schlagworte:
Arthritis
Arthritis, Rheumatoid
Blood Coagulation
Blood Coagulation Tests
Blood Platelets
Drug Therapy
Geriatrics
Gout
Humans
Male
Myocardial Infarction
Old Medline
Original
Phlebitis
Platelet Adhesiveness
Primary Myelofibrosis
Prothrombin Time
Sulfinpyrazone
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Zusammenfassung:Sulfinpyrazone (Anturan) administered in therapeutic doses over a period of several weeks produced prolongation of platelet survival and reduced turnover but with little change in blood coagulation. The changes in platelet survival and turnover were associated with reduced platelet adhesiveness. It is therefore possible to affect platelet economy in man significantly, without producing corresponding effects on blood coagulation.
ISSN:0008-4409