Vasocortin: a novel glucocorticoid‐induced anti‐inflammatory protein

The preliminary characterization of ‘vasocortin’ a novel glucocorticoid‐induced anti‐inflammatory protein, is described. Vasocortin is released into the rat peritoneal cavity following systemic dexamethasone administration, has an apparent mol. wt. of 100 kD and inhibits rat dextran oedema. Vasocort...

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Veröffentlicht in:	British journal of pharmacology 1987-03, Vol.90 (3), p.443-445
Hauptverfasser:	Carnuccio, Rosa, Rosa, Massimo, Guerrasio, Bruno, Iuvone, Teresa, Sautebin, Lidia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexins Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Glucocorticoids - pharmacology Glycoproteins - biosynthesis Glycoproteins - physiology Inflammation - physiopathology Inflammation - prevention & control Male Medical sciences Peritoneum - metabolism Pharmacology. Drug treatments Proteins - physiology Rats Rats, Inbred Strains Short Communication
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Beschreibung
Zusammenfassung:	The preliminary characterization of ‘vasocortin’ a novel glucocorticoid‐induced anti‐inflammatory protein, is described. Vasocortin is released into the rat peritoneal cavity following systemic dexamethasone administration, has an apparent mol. wt. of 100 kD and inhibits rat dextran oedema. Vasocortin is distinct from lipocortin and is likely to be associated with the anti‐inflammatory effect of glucocorticoids.
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1987.tb11193.x