Influence of contractile agonists on the mechanism of endothelium‐dependent relaxation in rat isolated mesenteric artery
This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase‐independent repolarization to acetylcholine‐evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre‐contraction. Noradrenaline‐induced con...
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| Veröffentlicht in: | British journal of pharmacology 1996-09, Vol.119 (2), p.191-193 |
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| creator | Plane, Frances Garland, Christopher J. |
| description | This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase‐independent repolarization to acetylcholine‐evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre‐contraction. Noradrenaline‐induced contractions were reversed by acetylcholine via both NO and NO synthase‐independent smooth muscle repolarization. In contrast, reversal of contractions to the thromboxane‐mimetic, U46619, by acetylcholine was entirely mediated by the actions of NO, independently of a change in membrane potential. |
| doi_str_mv | 10.1111/j.1476-5381.1996.tb15970.x |
| format | Article |
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Noradrenaline‐induced contractions were reversed by acetylcholine via both NO and NO synthase‐independent smooth muscle repolarization. In contrast, reversal of contractions to the thromboxane‐mimetic, U46619, by acetylcholine was entirely mediated by the actions of NO, independently of a change in membrane potential.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1996.tb15970.x</identifier><identifier>PMID: 8886397</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid ; Acetylcholine - pharmacology ; Animals ; Biological and medical sciences ; Blood vessels and receptors ; Drug Interactions ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; endothelium‐dependent hyperpolarization ; Enzyme Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Male ; Membrane Potentials - drug effects ; Mesenteric Artery, Superior - drug effects ; Mesenteric Artery, Superior - physiology ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; Muscle Relaxation - drug effects ; Muscle Relaxation - physiology ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - physiology ; NG-Nitroarginine Methyl Ester - pharmacology ; Nifedipine - pharmacology ; Nitric oxide ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitroarginine - pharmacology ; Norepinephrine - pharmacology ; Prostaglandin Endoperoxides, Synthetic - pharmacology ; Rats ; Rats, Wistar ; Stimulation, Chemical ; Thromboxane A2 - analogs & derivatives ; Thromboxane A2 - pharmacology ; vascular smooth muscle ; Vasoconstrictor Agents - pharmacology ; Vasodilator Agents - pharmacology ; Vertebrates: cardiovascular system</subject><ispartof>British journal of pharmacology, 1996-09, Vol.119 (2), p.191-193</ispartof><rights>1996 British Pharmacological Society</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5730-bdbe19c02c019c2110bbc038b0f3df6f79b2b4d50683bfb2420fbaf3bfffa9073</citedby><cites>FETCH-LOGICAL-c5730-bdbe19c02c019c2110bbc038b0f3df6f79b2b4d50683bfb2420fbaf3bfffa9073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915844/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915844/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3215837$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8886397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plane, Frances</creatorcontrib><creatorcontrib>Garland, Christopher J.</creatorcontrib><title>Influence of contractile agonists on the mechanism of endothelium‐dependent relaxation in rat isolated mesenteric artery</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase‐independent repolarization to acetylcholine‐evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre‐contraction. Noradrenaline‐induced contractions were reversed by acetylcholine via both NO and NO synthase‐independent smooth muscle repolarization. In contrast, reversal of contractions to the thromboxane‐mimetic, U46619, by acetylcholine was entirely mediated by the actions of NO, independently of a change in membrane potential.</description><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid</subject><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood vessels and receptors</subject><subject>Drug Interactions</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>endothelium‐dependent hyperpolarization</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Membrane Potentials - drug effects</subject><subject>Mesenteric Artery, Superior - drug effects</subject><subject>Mesenteric Artery, Superior - physiology</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle Relaxation - physiology</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nifedipine - pharmacology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitroarginine - pharmacology</subject><subject>Norepinephrine - pharmacology</subject><subject>Prostaglandin Endoperoxides, Synthetic - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stimulation, Chemical</subject><subject>Thromboxane A2 - analogs & derivatives</subject><subject>Thromboxane A2 - pharmacology</subject><subject>vascular smooth muscle</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUU1vEzEQtSpQCYWfUMmquO4yXu-HlwOiVEArVWoPcLZsr9042rUj2ykJJ34Cv5FfgpdEUTniy4zmvTcznofQBYGS5Pd2VZK6a4uGMlKSvm_LJEnTd1BuT9DiCD1DCwDoCkIYe4FexrgCyGDXnKJTxlhL-26Bftw4M260Uxp7g5V3KQiV7KixePDOxhSxdzgtNZ60WopcmWaidoPPxdFupt8_fw16nQvaJRz0KLYi2ayxDgeRsI1-FEkPWR8zQwersAg57l6h50aMUb8-xDP07fOnr1fXxe3dl5ury9tCNR2FQg5Sk15BpSCHihCQUgFlEgwdTGu6XlayHhpoGZVGVnUFRgqTc2NEDx09Q-_3fdcbOelB6fmPI18HO4mw415Y_i_i7JI_-EdOetKwus4N3u0bqOBjDNoctQT4bAhf8fnqfL46nw3hB0P4NovPn04_Sg8OZPzNARdRidEE4ZSNRxqt8g50pn3Y075nb3b_sQD_eH_9N6V_AFiIrzI</recordid><startdate>199609</startdate><enddate>199609</enddate><creator>Plane, Frances</creator><creator>Garland, Christopher J.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>199609</creationdate><title>Influence of contractile agonists on the mechanism of endothelium‐dependent relaxation in rat isolated mesenteric artery</title><author>Plane, Frances ; Garland, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5730-bdbe19c02c019c2110bbc038b0f3df6f79b2b4d50683bfb2420fbaf3bfffa9073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid</topic><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood vessels and receptors</topic><topic>Drug Interactions</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>endothelium‐dependent hyperpolarization</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Membrane Potentials - drug effects</topic><topic>Mesenteric Artery, Superior - drug effects</topic><topic>Mesenteric Artery, Superior - physiology</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle Relaxation - physiology</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nifedipine - pharmacology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitroarginine - pharmacology</topic><topic>Norepinephrine - pharmacology</topic><topic>Prostaglandin Endoperoxides, Synthetic - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stimulation, Chemical</topic><topic>Thromboxane A2 - analogs & derivatives</topic><topic>Thromboxane A2 - pharmacology</topic><topic>vascular smooth muscle</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plane, Frances</creatorcontrib><creatorcontrib>Garland, Christopher J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plane, Frances</au><au>Garland, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of contractile agonists on the mechanism of endothelium‐dependent relaxation in rat isolated mesenteric artery</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1996-09</date><risdate>1996</risdate><volume>119</volume><issue>2</issue><spage>191</spage><epage>193</epage><pages>191-193</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase‐independent repolarization to acetylcholine‐evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre‐contraction. Noradrenaline‐induced contractions were reversed by acetylcholine via both NO and NO synthase‐independent smooth muscle repolarization. In contrast, reversal of contractions to the thromboxane‐mimetic, U46619, by acetylcholine was entirely mediated by the actions of NO, independently of a change in membrane potential.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8886397</pmid><doi>10.1111/j.1476-5381.1996.tb15970.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 1996-09, Vol.119 (2), p.191-193 |
| issn | 0007-1188 1476-5381 |
| language | eng |
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| source | MEDLINE; Wiley Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Acetylcholine - pharmacology Animals Biological and medical sciences Blood vessels and receptors Drug Interactions Endothelium, Vascular - drug effects Endothelium, Vascular - physiology endothelium‐dependent hyperpolarization Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques Male Membrane Potentials - drug effects Mesenteric Artery, Superior - drug effects Mesenteric Artery, Superior - physiology Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology NG-Nitroarginine Methyl Ester - pharmacology Nifedipine - pharmacology Nitric oxide Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Norepinephrine - pharmacology Prostaglandin Endoperoxides, Synthetic - pharmacology Rats Rats, Wistar Stimulation, Chemical Thromboxane A2 - analogs & derivatives Thromboxane A2 - pharmacology vascular smooth muscle Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology Vertebrates: cardiovascular system |
| title | Influence of contractile agonists on the mechanism of endothelium‐dependent relaxation in rat isolated mesenteric artery |
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