Influence of contractile agonists on the mechanism of endothelium‐dependent relaxation in rat isolated mesenteric artery

This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase‐independent repolarization to acetylcholine‐evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre‐contraction. Noradrenaline‐induced con...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 1996-09, Vol.119 (2), p.191-193
Hauptverfasser:	Plane, Frances, Garland, Christopher J.
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Acetylcholine - pharmacology Animals Biological and medical sciences Blood vessels and receptors Drug Interactions Endothelium, Vascular - drug effects Endothelium, Vascular - physiology endothelium‐dependent hyperpolarization Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques Male Membrane Potentials - drug effects Mesenteric Artery, Superior - drug effects Mesenteric Artery, Superior - physiology Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology NG-Nitroarginine Methyl Ester - pharmacology Nifedipine - pharmacology Nitric oxide Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Norepinephrine - pharmacology Prostaglandin Endoperoxides, Synthetic - pharmacology Rats Rats, Wistar Stimulation, Chemical Thromboxane A2 - analogs & derivatives Thromboxane A2 - pharmacology vascular smooth muscle Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology Vertebrates: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase‐independent repolarization to acetylcholine‐evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre‐contraction. Noradrenaline‐induced contractions were reversed by acetylcholine via both NO and NO synthase‐independent smooth muscle repolarization. In contrast, reversal of contractions to the thromboxane‐mimetic, U46619, by acetylcholine was entirely mediated by the actions of NO, independently of a change in membrane potential.
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1996.tb15970.x