The non‐peptide NK1 receptor antagonist, (±)‐CP‐96,345, produces antinociceptive and anti‐oedema effects in the rat

The non‐peptide NK1 receptor antagonist, (±)‐CP‐96,345, has been evaluated for antinociceptive activity in two well‐characterized inflammatory pain models in the rat. (±)‐CP‐96,345 abolished carrageenin‐induced mechanical hyperalgesia, significantly reduced carrageenin‐induced paw oedema and attenua...

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Veröffentlicht in:	British journal of pharmacology 1992-03, Vol.105 (3), p.508-510
Hauptverfasser:	Birch, P.J., Harrison, S.M., Hayes, A.G., Rogers, H., Tyers, M.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	(±)‐CP‐96,345 Analgesics Analgesics - pharmacology Animals antinociception anti‐oedema Behavior, Animal - drug effects Biological and medical sciences Biphenyl Compounds - pharmacology Carrageenan Edema - chemically induced Edema - drug therapy Formaldehyde Male Medical sciences Neuropharmacology non‐peptide NR1 receptor antagonist Pain - chemically induced Pharmacology. Drug treatments Rats Rats, Inbred Strains Receptors, Neurokinin-2 Receptors, Neurotransmitter - antagonists & inhibitors Receptors, Neurotransmitter - drug effects
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Beschreibung
Zusammenfassung:	The non‐peptide NK1 receptor antagonist, (±)‐CP‐96,345, has been evaluated for antinociceptive activity in two well‐characterized inflammatory pain models in the rat. (±)‐CP‐96,345 abolished carrageenin‐induced mechanical hyperalgesia, significantly reduced carrageenin‐induced paw oedema and attenuated the second phase of the formalin response. The results suggest that NK1 receptor activation occurs during the induction of inflammatory pain states in the rat.
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1992.tb09008.x