Disseminated cytomegalovirus infection in immunodeficient rhesus monkeys

Rhesus monkeys experimentally infected with the lentivirus SIV/Delta become immunodeficient and often die of opportunistic infections. The most frequent of these is cytomegalovirus (CMV). The lesions due to reactivated CMV infection in 14 SIV-infected monkeys were reviewed. Changes due to CMV were o...

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Veröffentlicht in:	The American journal of pathology 1987-11, Vol.129 (2), p.345-352
1. Verfasser:	Baskin, GB
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Arteries - pathology Biological and medical sciences Brain - pathology cytomegalovirus Cytomegalovirus - isolation & purification Cytomegalovirus Infections - complications Cytomegalovirus Infections - pathology Experimental viral diseases and models Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - pathology Infectious diseases Intestine, Small - pathology Liver - pathology Lung - pathology Lymph Nodes - pathology Macaca fascicularis Macaca mulatta Male Medical sciences Peripheral Nerves - pathology simian immunodeficiency virus Spleen - pathology Testis - pathology Viral diseases
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Beschreibung
Zusammenfassung:	Rhesus monkeys experimentally infected with the lentivirus SIV/Delta become immunodeficient and often die of opportunistic infections. The most frequent of these is cytomegalovirus (CMV). The lesions due to reactivated CMV infection in 14 SIV-infected monkeys were reviewed. Changes due to CMV were observed in the brain, lung, lymph node, liver, spleen, small intestine, testicle, nerves, and arteries. Disseminated CMV infection in immunodeficient rhesus monkeys is a useful model for studying the pathogenesis, treatment, and prevention of similar infections in immunodeficient human beings.
ISSN:	0002-9440 1525-2191