The Dynamics of Signal Triggering in a gp130-Receptor Complex
gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containi...
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| Veröffentlicht in: | Structure (London) 2007-04, Vol.15 (4), p.441-448 |
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| container_title | Structure (London) |
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| creator | Matadeen, Rishi Hon, Wai-Ching Heath, John K. Jones, E. Yvonne Fuller, Stephen |
| description | gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade. |
| doi_str_mv | 10.1016/j.str.2007.02.006 |
| format | Article |
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Yvonne</creatorcontrib><creatorcontrib>Fuller, Stephen</creatorcontrib><title>The Dynamics of Signal Triggering in a gp130-Receptor Complex</title><title>Structure (London)</title><addtitle>Structure</addtitle><description>gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.</description><subject>Animals</subject><subject>Cryoelectron Microscopy</subject><subject>Cytokine Receptor gp130 - chemistry</subject><subject>Cytokine Receptor gp130 - metabolism</subject><subject>Interleukin-11 - chemistry</subject><subject>Interleukin-11 - physiology</subject><subject>Mice</subject><subject>MOLIMMUNO</subject><subject>Protein Binding</subject><subject>Receptors, Interleukin-11 - chemistry</subject><subject>Receptors, Interleukin-11 - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>SIGNALING</subject><issn>0969-2126</issn><issn>1878-4186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVoabZpHyCX4lNvdmdkWbYpKYRtkwYChWR7FrI8crTYlit5Q_L2ddilTS45zWH-_5vhY-wUIUNA-WWbxTlkHKDMgGcA8oitsCqrVGAl37AV1LJOOXJ5zN7HuAUAXgC8Y8dYirwsUa7Y2eaOku-Pox6ciYm3ya3rRt0nm-C6joIbu8SNiU66CXNIb8jQNPuQrP0w9fTwgb21uo_08TBP2O-LH5v1z_T61-XV-vw6NQUWcyoqTUYIwgrE8pIRtUWhpW3yBrFsbMFb2zQCUNTISYoWjBXI66qVlhOY_IR923OnXTNQa2icg-7VFNygw6Py2qmXm9Hdqc7fK6yqopblAvh8AAT_Z0dxVoOLhvpej-R3UZWQ16LO8yWI-6AJPsZA9t8RBPUkXW3VIl09SVfA1SJ96Xx6_t3_xsHyEvi6D9Di6N5RUNE4Gg21LpCZVevdK_i_V6uSJA</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Matadeen, Rishi</creator><creator>Hon, Wai-Ching</creator><creator>Heath, John K.</creator><creator>Jones, E. 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| ispartof | Structure (London), 2007-04, Vol.15 (4), p.441-448 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Cryoelectron Microscopy Cytokine Receptor gp130 - chemistry Cytokine Receptor gp130 - metabolism Interleukin-11 - chemistry Interleukin-11 - physiology Mice MOLIMMUNO Protein Binding Receptors, Interleukin-11 - chemistry Receptors, Interleukin-11 - metabolism Signal Transduction - physiology SIGNALING |
| title | The Dynamics of Signal Triggering in a gp130-Receptor Complex |
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