The Dynamics of Signal Triggering in a gp130-Receptor Complex

gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containi...

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Veröffentlicht in:	Structure (London) 2007-04, Vol.15 (4), p.441-448
Hauptverfasser:	Matadeen, Rishi, Hon, Wai-Ching, Heath, John K., Jones, E. Yvonne, Fuller, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cryoelectron Microscopy Cytokine Receptor gp130 - chemistry Cytokine Receptor gp130 - metabolism Interleukin-11 - chemistry Interleukin-11 - physiology Mice MOLIMMUNO Protein Binding Receptors, Interleukin-11 - chemistry Receptors, Interleukin-11 - metabolism Signal Transduction - physiology SIGNALING
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Beschreibung
Zusammenfassung:	gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.
ISSN:	0969-2126 1878-4186
DOI:	10.1016/j.str.2007.02.006