Subclinical alteration of taste sensitivity induced by candesartan in healthy subjects

Aims There have been case reports of taste disturbance for the angiotensin II receptor blockers losartan and valsartan, but not for candesartan. This study was undertaken to examine whether candesartan causes taste disturbance. Methods Candesartan cilexetil (4 mg day−1) or vehicle was given to healthy volunteers (n = 8) for 7 days in a randomized, double‐blind, placebo‐controlled, cross‐over design with a 2‐week washout period. Clinical gustometry using the filter‐paper disc test and electrogustometry were sequentially performed before and at the end of each trial. Serum and salivary zinc concentrations were also measured. Results Detection thresholds of four basic tastes (sweet, salty, sour and bitter) determined by the paper disc test were significantly (P