Purpura associated with hypergammaglobulinemia, renal tubular acidosis and osteomalacia

Two patients with hyperglobulinemia associated with purpura were studied. One had features of Sjögren's syndrome, while the other appeared to have a primary condition -- "chronic benign purpura". Both patients also had renal tubular acidosis, osteomalacia and renal calculi, with distu...

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Veröffentlicht in:	Canadian Medical Association journal 1977-01, Vol.116 (1), p.53-58
Hauptverfasser:	Marquez-Julio, A, Rapoport, A, Wilansky, D. L, Rabinovich, S, Chamberlain, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium Acidosis, Renal Tubular - complications Acidosis, Renal Tubular - diagnosis Blood Proteins - analysis Electrolytes - blood Female Humans Ilium - pathology Immunoglobulins - analysis Kidney - pathology Kidney Function Tests Middle Aged Osteomalacia - complications Osteomalacia - diagnosis Purpura, Hyperglobulinemic - complications Purpura, Hyperglobulinemic - diagnosis Sjogren's Syndrome - complications Sjogren's Syndrome - diagnosis Skin - pathology
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Zusammenfassung:	Two patients with hyperglobulinemia associated with purpura were studied. One had features of Sjögren's syndrome, while the other appeared to have a primary condition -- "chronic benign purpura". Both patients also had renal tubular acidosis, osteomalacia and renal calculi, with disturbed calcium metabolism and acid-base balance. Autoantibodies were detected in the serum of both patients, and mononuclear cell infiltrates were noted in skin and kidney biopsies from both.
ISSN:	0008-4409