Fluorous 2-chloropyridinium salt (Mukaiyama condensation reagent) for amide formation reactions

Fluorous 2-chloropyridinium salt (Mukaiyama condensation reagent) for amide formation reactions

A new fluorous 2-chloropyridinium salt was prepared, and was applied in amide formation reactions. A new fluorous 2-chloropyridinium hexafluorophosphate was prepared as a modified Mukaiyama condensation reagent, and it was applied in amide formation reactions. Good to excellent purities of amides we...

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Veröffentlicht in:Tetrahedron letters 2005-09, Vol.46 (38), p.6585-6588
Hauptverfasser: Nagashima, Tadamichi, Lu, Yimin, Petro, Michael J., Zhang, Wei
Format: Artikel
Sprache:eng
Schlagworte:
Amide coupling
Fluorous reagent
Fluorous solid-phase extraction
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Zusammenfassung:A new fluorous 2-chloropyridinium salt was prepared, and was applied in amide formation reactions. A new fluorous 2-chloropyridinium hexafluorophosphate was prepared as a modified Mukaiyama condensation reagent, and it was applied in amide formation reactions. Good to excellent purities of amides were obtained after fluorous solid-phase extraction of reaction mixtures without additional chromatography.
ISSN:0040-4039
0957-4166
1873-3581
1362-511X
DOI:10.1016/j.tetlet.2005.07.072