e19a2 BCR–ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases
This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fu...
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| Veröffentlicht in: | Journal of clinical pathology 2006-10, Vol.59 (10), p.1102-1103 |
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| container_title | Journal of clinical pathology |
| container_volume | 59 |
| creator | Mondal, B C Majumdar, S Dasgupta, U B Chaudhuri, U Chakrabarti, P Bhattacharyya, S |
| description | This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fusion transcript e19a2. This finding suggests that CML carrying μ-BCR breakpoint may exhibit a clinical course similar to typical CML. |
| doi_str_mv | 10.1136/jcp.2005.029595 |
| format | Article |
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Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fusion transcript e19a2. This finding suggests that CML carrying μ-BCR breakpoint may exhibit a clinical course similar to typical CML.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2005.029595</identifier><identifier>PMID: 17021137</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adult ; Bone marrow ; Case Report ; chronic myeloid leukaemia ; CML ; Disease Progression ; Fatal Outcome ; Fusion Proteins, bcr-abl - genetics ; Genes ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics ; Lymphatic system ; Male ; Molecular weight ; Neutrophils ; Polymerase chain reaction ; Proteins ; Reverse Transcriptase Polymerase Chain Reaction - methods ; Transcription, Genetic</subject><ispartof>Journal of clinical pathology, 2006-10, Vol.59 (10), p.1102-1103</ispartof><rights>Copyright 2006 Journal of Clinical Pathology</rights><rights>Copyright: 2006 Copyright 2006 Journal of Clinical Pathology</rights><rights>Copyright © 2006 The BMJ Publishing Group and the Association of Clinical Pathologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jcp.bmj.com/content/59/10/1102.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jcp.bmj.com/content/59/10/1102.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,723,776,780,881,23550,27901,27902,53766,53768,77342,77373</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17021137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mondal, B C</creatorcontrib><creatorcontrib>Majumdar, S</creatorcontrib><creatorcontrib>Dasgupta, U B</creatorcontrib><creatorcontrib>Chaudhuri, U</creatorcontrib><creatorcontrib>Chakrabarti, P</creatorcontrib><creatorcontrib>Bhattacharyya, S</creatorcontrib><title>e19a2 BCR–ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fusion transcript e19a2. This finding suggests that CML carrying μ-BCR breakpoint may exhibit a clinical course similar to typical CML.</description><subject>Adult</subject><subject>Bone marrow</subject><subject>Case Report</subject><subject>chronic myeloid leukaemia</subject><subject>CML</subject><subject>Disease Progression</subject><subject>Fatal Outcome</subject><subject>Fusion Proteins, bcr-abl - genetics</subject><subject>Genes</subject><subject>Humans</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Molecular weight</subject><subject>Neutrophils</subject><subject>Polymerase chain reaction</subject><subject>Proteins</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>Transcription, Genetic</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkl9rFDEUxYNY7Lb67JsEBB-EWXMnmWTGB6FdqhWWWsQ_UJCQzdyx2c5MxmRG3Te_Q79hP4kpW-ufF58ul_PjcG5yCHkIbA7A5bO1HeY5Y8Wc5VVRFXfIDITKMwFC3iUzxnLIKiXkLtmLcc0YcAX8HtkFlZS0zMgnhMrk9HDx9urH5cHhkjZTdL6nYzB9tMENI3Vp2wzOmpba8-B7Z2m3wda7mrY4XRjsnHlODQ04-DBS39Dxm6fWRIz3yU5j2ogPbuY-ef_y6N3iOFu-efV6cbDMVoKrMWuEqEEKkFjIkq0KZVBwUaKQCA1XUtjSIsMSTG1rI1EV6Q7GTSUYB1UJvk9ebH2HadVhbbFP-Vs9BNeZsNHeOP230rtz_dl_1VBKUAUkgyc3BsF_mTCOunPRYtuaHv0UtSyrXJWy-i8IleIpk0rg43_AtZ9Cn15BgyqB5TKXLFGP_gx-m_jXByUg2wIujvj9VjfhQkvFVaFPPiz08uyjkKenZ_ok8U-3_Kpb_3Zj-rotOrVFX7dFb9vCfwJtXK6e</recordid><startdate>200610</startdate><enddate>200610</enddate><creator>Mondal, B C</creator><creator>Majumdar, S</creator><creator>Dasgupta, U B</creator><creator>Chaudhuri, U</creator><creator>Chakrabarti, P</creator><creator>Bhattacharyya, S</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200610</creationdate><title>e19a2 BCR–ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases</title><author>Mondal, B C ; 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| subjects | Adult Bone marrow Case Report chronic myeloid leukaemia CML Disease Progression Fatal Outcome Fusion Proteins, bcr-abl - genetics Genes Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Lymphatic system Male Molecular weight Neutrophils Polymerase chain reaction Proteins Reverse Transcriptase Polymerase Chain Reaction - methods Transcription, Genetic |
| title | e19a2 BCR–ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases |
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