e19a2 BCR–ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases

This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fu...

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Veröffentlicht in:	Journal of clinical pathology 2006-10, Vol.59 (10), p.1102-1103
Hauptverfasser:	Mondal, B C, Majumdar, S, Dasgupta, U B, Chaudhuri, U, Chakrabarti, P, Bhattacharyya, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bone marrow Case Report chronic myeloid leukaemia CML Disease Progression Fatal Outcome Fusion Proteins, bcr-abl - genetics Genes Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Lymphatic system Male Molecular weight Neutrophils Polymerase chain reaction Proteins Reverse Transcriptase Polymerase Chain Reaction - methods Transcription, Genetic
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Zusammenfassung:	This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fusion transcript e19a2. This finding suggests that CML carrying μ-BCR breakpoint may exhibit a clinical course similar to typical CML.
ISSN:	0021-9746 1472-4146
DOI:	10.1136/jcp.2005.029595