Gastric carcinogenesis after long-term observation of clinical course without any treatment in a patient with attenuated familial adenomatous polyposis

In a recent detailed examination of the upper gastrointestinal tract, Borr type III gastric cancer was found, with many hepatic metastasis lesions and many polyps in the fundic gland (fig 1A,B). Expression of protein was found and it was not considered possible that carcinogenesis resulted from atypia of the fundic gland polyp. [...]in this case, as a mechanism of gastric carcinogenesis rather than conventional carcinogenesis from adenoma or atypical transformation of fundic gland polyp in the foci of atypical cells in normal gastric mucosa, malignancy was induced via expression of p53 or cytokeratin 7.