Aberrant maspin expression in gallbladder epithelium is associated with intestinal metaplasia in patients with cholelithiasis

Objective: Aberrant expression of maspin protein related to DNA hypomethylation in the promoter region is frequently observed in gallbladder carcinomas, whereas the non-tumorous gallbladder epithelium is maspin negative. We investigated maspin expression in non-tumorous gallbladder epithelium in pat...

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Veröffentlicht in:	Journal of clinical pathology 2006-03, Vol.59 (3), p.328-330
Hauptverfasser:	Maesawa, C, Ogasawara, S, Yashima-Abo, A, Kimura, T, Kotani, K, Masuda, S, Nagata, Y, Iwaya, T, Suzuki, K, Oyake, T, Akiyama, Y, Kawamura, H, Masuda, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biomarkers, Tumor - analysis Case-Control Studies cholelithiasis Cholelithiasis - chemistry Cholelithiasis - pathology Deoxyribonucleic acid Disease Progression DNA DNA methylation Endothelium - chemistry Endothelium - pathology Epigenetics Female Gallbladder Gallbladder - chemistry Gallbladder - pathology gallbladder carcinoma Gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Gene expression Genes, Tumor Suppressor Humans Immunohistochemistry - methods intestinal metaplasia Intestinal Mucosa - pathology Investigative techniques, diagnostic techniques (general aspects) Localization Male maspin Medical sciences Metaplasia Metastasis Middle Aged Morphology Motility Mucous membrane Other diseases. Semiology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein expression Proteins Serpins - analysis Short Report Stomach Neoplasms - chemistry Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Studies TFF trefoil factor family Tumors
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Zusammenfassung:	Objective: Aberrant expression of maspin protein related to DNA hypomethylation in the promoter region is frequently observed in gallbladder carcinomas, whereas the non-tumorous gallbladder epithelium is maspin negative. We investigated maspin expression in non-tumorous gallbladder epithelium in patients with cholelithiasis. Methods: An immunohistochemical study of maspin expression was performed in 69 patients with cholelithiasis and 30 patients with gastric cancer without cholelithiasis. Results: Immunoreactivity for maspin was observed in focal and patchy regions of the gallbladder epithelium. Positive immunoreactivity for maspin was significantly associated with the presence of intestinal metaplasia in patients with cholelithiasis (p
ISSN:	0021-9746 1472-4146
DOI:	10.1136/jcp.2005.027284