Suramin: a reversible P2‐purinoceptor antagonist in the mouse vas deferens
The trypanocide Suramin was tested as a possible antagonist at the P2‐purinoceptor of the mouse vas deferens. At a concentration of 100 μm, Suramin antagonized the response to α,β‐methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may pr...
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| Veröffentlicht in: | British journal of pharmacology 1988-02, Vol.93 (2), p.243-245 |
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| container_title | British journal of pharmacology |
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| creator | Dunn, P.M. Blakeley, A.G.H. |
| description | The trypanocide Suramin was tested as a possible antagonist at the P2‐purinoceptor of the mouse vas deferens. At a concentration of 100 μm, Suramin antagonized the response to α,β‐methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2‐purinoceptors. |
| doi_str_mv | 10.1111/j.1476-5381.1988.tb11427.x |
| format | Article |
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At a concentration of 100 μm, Suramin antagonized the response to α,β‐methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2‐purinoceptors.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1988.tb11427.x</identifier><identifier>PMID: 3359103</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenosine Diphosphate - analogs & derivatives ; Adenosine Diphosphate - pharmacology ; Animals ; Applied sciences ; Biological and medical sciences ; Exact sciences and technology ; In Vitro Techniques ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Miscellaneous ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Neuropharmacology ; Neurotransmitters. 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At a concentration of 100 μm, Suramin antagonized the response to α,β‐methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2‐purinoceptors.</description><subject>Adenosine Diphosphate - analogs & derivatives</subject><subject>Adenosine Diphosphate - pharmacology</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Exact sciences and technology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Miscellaneous</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Other techniques and industries</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Purinergic - drug effects</subject><subject>Suramin - pharmacology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFO3DAQhq2qCLa0j4BkVRW3pB47iZ0eqraoFKSVilQ4W04yAa8SZ2snC9z6CH3GPgleiFZwqi_j0ffrH838hLwHlkJ8H1cpZLJIcqEghVKpdKwAMi7Tu1dksUOvyYIxJhMApQ7ImxBWjEUo832yL0ReAhMLsvw1edNb94ka6nGDPtiqQ3rB__35u568dUON63Hw1LjRXA_OhpFaR8cbpP0wBaQbE2iDLXp04S3Za00X8N1cD8nV6ffLk7Nk-fPH-cnXZbLKWCmTIlOCy1LmKjN5UZVFbWLfAGOq4nWroGgL0TQSeWUYa4UsoQDelKoVuWp5Iw7J5yff9VT12NToRm86vfa2N_5eD8bql8TZG309bDSoeBhWRIPj2cAPvycMo-5tqLHrjMO4lZYKFGNZGYVHzyftRsz3i_zDzE2oTdd642obdjLJ4pJc_V8GPHuUfXmS3doO73cYmN7Grld6m63eZqu3ses5dn2nv12cPX7FA8ZVoog</recordid><startdate>198802</startdate><enddate>198802</enddate><creator>Dunn, P.M.</creator><creator>Blakeley, A.G.H.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198802</creationdate><title>Suramin: a reversible P2‐purinoceptor antagonist in the mouse vas deferens</title><author>Dunn, P.M. ; Blakeley, A.G.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j4097-64832797584a56b96ca327d1008b2cf816f63dd7e2ba00f3791612d98f358f2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adenosine Diphosphate - analogs & derivatives</topic><topic>Adenosine Diphosphate - pharmacology</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Exact sciences and technology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Miscellaneous</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Other techniques and industries</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, Purinergic - drug effects</topic><topic>Suramin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dunn, P.M.</creatorcontrib><creatorcontrib>Blakeley, A.G.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dunn, P.M.</au><au>Blakeley, A.G.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suramin: a reversible P2‐purinoceptor antagonist in the mouse vas deferens</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1988-02</date><risdate>1988</risdate><volume>93</volume><issue>2</issue><spage>243</spage><epage>245</epage><pages>243-245</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>The trypanocide Suramin was tested as a possible antagonist at the P2‐purinoceptor of the mouse vas deferens. At a concentration of 100 μm, Suramin antagonized the response to α,β‐methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2‐purinoceptors.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3359103</pmid><doi>10.1111/j.1476-5381.1988.tb11427.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1188 |
| ispartof | British journal of pharmacology, 1988-02, Vol.93 (2), p.243-245 |
| issn | 0007-1188 1476-5381 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1853806 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - pharmacology Animals Applied sciences Biological and medical sciences Exact sciences and technology In Vitro Techniques Male Medical sciences Mice Mice, Inbred C57BL Miscellaneous Muscle Contraction - drug effects Muscle, Smooth - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Other techniques and industries Pharmacology. Drug treatments Receptors, Purinergic - drug effects Suramin - pharmacology |
| title | Suramin: a reversible P2‐purinoceptor antagonist in the mouse vas deferens |
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