Suramin: a reversible P2‐purinoceptor antagonist in the mouse vas deferens

The trypanocide Suramin was tested as a possible antagonist at the P2‐purinoceptor of the mouse vas deferens. At a concentration of 100 μm, Suramin antagonized the response to α,β‐methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may pr...

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Veröffentlicht in:	British journal of pharmacology 1988-02, Vol.93 (2), p.243-245
Hauptverfasser:	Dunn, P.M., Blakeley, A.G.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - pharmacology Animals Applied sciences Biological and medical sciences Exact sciences and technology In Vitro Techniques Male Medical sciences Mice Mice, Inbred C57BL Miscellaneous Muscle Contraction - drug effects Muscle, Smooth - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Other techniques and industries Pharmacology. Drug treatments Receptors, Purinergic - drug effects Suramin - pharmacology
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Beschreibung
Zusammenfassung:	The trypanocide Suramin was tested as a possible antagonist at the P2‐purinoceptor of the mouse vas deferens. At a concentration of 100 μm, Suramin antagonized the response to α,β‐methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2‐purinoceptors.
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1988.tb11427.x