Down-Regulation of Caveolin-1, a Candidate Tumor Suppressor Gene, in Sarcomas

Caveolae are plasma membrane microdomains that have been implicated in the regulation of several intracellular signaling pathways. Previous studies suggest that caveolin-1, the main structural protein of caveolae, could function as a tumor suppressor. Caveolin-1 is highly expressed in terminally dif...

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Veröffentlicht in:	The American journal of pathology 2001-03, Vol.158 (3), p.833-839
Hauptverfasser:	Wiechen, Kai, Sers, Christine, Agoulnik, Alexander, Arlt, Katharina, Dietel, Manfred, Schlag, Peter M., Schneider, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Caveolin 1 Caveolins - genetics Caveolins - immunology Caveolins - metabolism Cell Division Cell Line Dermatology Down-Regulation - drug effects Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Genes, Tumor Suppressor Humans Immunohistochemistry Medical sciences Neoplasms, Adipose Tissue - metabolism Neoplasms, Fibrous Tissue - metabolism Neoplasms, Muscle Tissue - metabolism Neoplasms, Vascular Tissue - metabolism Sarcoma - genetics Sarcoma - metabolism Sarcoma - pathology Short Communications Transfection Tumor Cells, Cultured Tumors of the skin and soft tissue. Premalignant lesions
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