Fully Virulent Bacillus anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis

Fully Virulent Bacillus anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis

The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant (bclA) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infect...

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Veröffentlicht in:Infection and Immunity 2007-01, Vol.75 (1), p.508-511
Hauptverfasser: Bozue, J, Cote, C.K, Moody, K.L, Welkos, S.L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anthrax - immunology
Bacillus anthracis
Bacillus anthracis - immunology
Bacillus anthracis - pathogenicity
Disease Models, Animal
Guinea Pigs
Immunodominant Epitopes - immunology
Membrane Glycoproteins - immunology
Mice
Mice, Inbred BALB C
Molecular Pathogenesis
Spores, Bacterial - immunology
Virulence
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Zusammenfassung:The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant (bclA) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infection despite the bclA deletion.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.01202-06