Allelic polymorphisms in the repeat and promoter regions of the interleukin‐4 gene and malaria severity in Ghanaian children

Allelic polymorphisms in the repeat and promoter regions of the interleukin‐4 gene and malaria severity in Ghanaian children

SUMMARY Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)‐4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between  polymorphisms  in  the  IL‐4  repeat  region  (intron  3)  and  promoter  regions...

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Veröffentlicht in:Clinical and experimental immunology 2004-10, Vol.138 (1), p.145-150
Hauptverfasser: GYAN, B. A., GOKA, B., CVETKOVIC, J. T., KURTZHALS, J. L., ADABAYERI, V., PERLMANN, H., LEFVERT, A.‐K., AKANMORI, B. D., TROYE‐BLOMBERG, M.
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Antibodies, Protozoan - blood
Biological and medical sciences
Child
Child, Preschool
falciparum
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gene Frequency
Genotype
Ghana - epidemiology
Humans
IgE
IL‐4 polymorphism
Immunoglobulin E - blood
Immunoglobulin E - genetics
Immunopathology
Infant
Interleukin-4 - genetics
Linkage Disequilibrium - genetics
Malaria
Malaria, Cerebral - epidemiology
Malaria, Cerebral - genetics
Malaria, Cerebral - immunology
Malaria, Falciparum - epidemiology
Malaria, Falciparum - genetics
Malaria, Falciparum - immunology
Medical sciences
Original
Parasitemia - blood
Parasitemia - immunology
pathogenesis
Plasmodium
Polymorphism, Genetic - genetics
Promoter Regions, Genetic - genetics
Repetitive Sequences, Nucleic Acid - genetics
severe malaria
Severity of Illness Index
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Zusammenfassung:SUMMARY Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)‐4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between  polymorphisms  in  the  IL‐4  repeat  region  (intron  3)  and  promoter  regions  (IL‐4 +33CT  and − 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL‐4 intron‐3 B1B1 genotype in the cerebral malaria group [P 
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2004.02590.x