Enhancement of Methyldopa Metabolism with Barbiturate

The spurious increase in serum catecholamine levels associated with methyldopa treatment can be reduced by the simultaneous administration of phenobarbitone. This accelerating effect of phenobarbitone on methyldopa metabolism has been demonstrated in relation to both adrenaline and noradrenaline, an...

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Veröffentlicht in:	BMJ 1971-08, Vol.3 (5773), p.518-519
Hauptverfasser:	Káldor, A., Juvancz, P., Demeczky, M., Sebestyen, K., Palotas, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Barbiturates Catecholamines Catecholamines - blood Enzyme Induction - drug effects Enzymes Epinephrine - blood Humans Hypertension - drug therapy Liver - metabolism Medical research Medication administration Metabolism Methyldopa - metabolism Methyldopa - therapeutic use Microsomes, Liver - enzymology Norepinephrine Norepinephrine - blood Papers and Originals Pharmacology Phenobarbital - pharmacology Preliminary Communications Research methods Tweed
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Beschreibung
Zusammenfassung:	The spurious increase in serum catecholamine levels associated with methyldopa treatment can be reduced by the simultaneous administration of phenobarbitone. This accelerating effect of phenobarbitone on methyldopa metabolism has been demonstrated in relation to both adrenaline and noradrenaline, and investigations suggest that it is due to the effect of barbiturate on the activity of metabolizing enzymes.
ISSN:	0007-1447 0959-8138 1468-5833
DOI:	10.1136/bmj.3.5773.518