Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems

Objective: To study in parallel the outflow of the sympathetic nervous system (SNS) and the hypothalamic-pituitary adrenal (HPA) axis tone in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Methods: 32 patients with SLE, 62 with RA, and 65 healthy subjects (HS) were included. To me...

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Veröffentlicht in:	Annals of the rheumatic diseases 2006-01, Vol.65 (1), p.51-56
Hauptverfasser:	Härle, P, Straub, R H, Wiest, R, Mayer, A, Schölmerich, J, Atzeni, F, Carrabba, M, Cutolo, M, Sarzi-Puttini, P
Format:	Artikel
Sprache:	eng
Schlagworte:	ACR ACTH Adalimumab adrenal hormones adrenocorticotropic hormone Adrenocorticotropic Hormone - blood Adult American College of Rheumatology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - physiopathology Biological and medical sciences corticotropin-releasing hormone CRH Diseases of the osteoarticular system Extended Report Female Glucocorticoids - therapeutic use healthy subjects HPA Humans Hydrocortisone - blood hypothalamic-pituitary-adrenal Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiopathology Inflammatory joint diseases interleukin Kinases Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - physiopathology Male Medical sciences Middle Aged neuropeptide Y Neuropeptide Y - blood NPY Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiopathology Prednisolone - therapeutic use Rheumatoid arthritis Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index SLE SLE Disease Activity Index SLEDAI SNS Studies sympathetic nervous system Sympathetic Nervous System - physiopathology sympathetic nervous system hormones systemic lupus erythematosus TNF Tumor Necrosis Factor-alpha - antagonists & inhibitors tumour necrosis factor
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Zusammenfassung:	Objective: To study in parallel the outflow of the sympathetic nervous system (SNS) and the hypothalamic-pituitary adrenal (HPA) axis tone in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Methods: 32 patients with SLE, 62 with RA, and 65 healthy subjects (HS) were included. To measure the tone of the HPA axis, plasma ACTH and serum cortisol were determined. Serum neuropeptide Y (NPY) was used to evaluate the sympathetic outflow. Results: Patients with SLE had increased NPY levels in comparison with HS, irrespective of prior prednisolone treatment (p
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.2005.038059