PHENYTOIN INHIBITION OF PARATHYROID HORMONE INDUCED BONE RESORPTION in vitro

PHENYTOIN INHIBITION OF PARATHYROID HORMONE INDUCED BONE RESORPTION in vitro

1 A study is reported of the effects of phenytoin and phenobarbitone on bone calcium mobilization by parathyroid hormone in vitro. 2 In a therapeutic concentration (15 μg/ml), phenytoin significantly inhibited parathyroid hormone‐induced calcium release from bone. 3 The inhibitory effect of phenytoi...

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Veröffentlicht in:British journal of pharmacology 1974-03, Vol.50 (3), p.405-408
Hauptverfasser: HARRIS, M., JENKINS, M.V., WILLS, M.R.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bone Resorption - drug effects
Calcium - metabolism
Calcium Radioisotopes
Clinical Pharmacology
Culture Media
Culture Techniques
Hypocalcemia - metabolism
Mice
Parathyroid Hormone - antagonists & inhibitors
Phenobarbital - pharmacology
Phenytoin - administration & dosage
Phenytoin - pharmacology
Proteins - metabolism
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Zusammenfassung:1 A study is reported of the effects of phenytoin and phenobarbitone on bone calcium mobilization by parathyroid hormone in vitro. 2 In a therapeutic concentration (15 μg/ml), phenytoin significantly inhibited parathyroid hormone‐induced calcium release from bone. 3 The inhibitory effect of phenytoin on bone calcium mobilization could play a role in the maintenance of hypocalcaemia in epileptic patients on long‐term anticonvulsant drug therapy.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1974.tb09616.x