Gastrointestinal intraepithelial lymphocytes and T cell lymphomas

[...]it cannot be excluded that the neoplastic IELs in cryptic EITCL, as supported by the identification of similar clones in peripheral blood of some RCS patients, recirculate between the small intestinal epithelium and other organs such as the gastric or colonic mucosae, skin, liver, and mesenteric lymph nodes. 3 Specific adhesion and chemokine receptor molecules potentially involved in homing of neoplastic IELs to all of these sites remain to be clarified.