Immune response towards lipid peroxidation products as a predictor of progression of non-alcoholic fatty liver disease to advanced fibrosis

Aims: Factors responsible for the progression of non-alcoholic fatty liver disease (NAFLD) to more severe liver injury are poorly understood. In the present study, we investigated the association between immune reactions triggered by oxidative stress and stage of NAFLD. Methods: Titres of IgG agains...

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Veröffentlicht in:	Gut 2005-07, Vol.54 (7), p.987-993
Hauptverfasser:	Albano, E, Mottaran, E, Vidali, M, Reale, E, Saksena, S, Occhino, G, Burt, A D, Day, C P
Format:	Artikel
Sprache:	eng
Schlagworte:	4-dihydropyridine-3 4-HNE 4-hydroxynonenal 4-methyl-1 5-dicarbaldehyde AAHP-HSA Adult Aged arachidonic acid hydroperoxide adduct with human serum albumin aspartate aminotransferase/alanine aminotransferase AST/ALT Autoantibodies - blood Biological and medical sciences Biomarkers - blood BMI body mass index Diabetes. Impaired glucose tolerance Disease Progression ELISA Endocrine pancreas. Apud cells (diseases) Endocrinopathies enzyme linked immunoabsorbent assay Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Liver - complications Fatty Liver - immunology Female Gastroenterology. Liver. Pancreas. Abdomen HSA HSC human hepatic stellate cells human serum albumin Humans immune mechanisms Immunoglobulin G - blood Laboratories Lipid Peroxidation - immunology Liver cirrhosis Liver Cirrhosis - etiology Liver Cirrhosis - immunology Liver Disease liver fibrosis Liver. Biliary tract. Portal circulation. Exocrine pancreas Logistic Models Male Malondialdehyde - immunology malondialdehyde adduct with human serum albumin MDA-HSA MDD Medical sciences Metabolic diseases Middle Aged NAFLD NASH non-alcoholic fatty liver disease non-alcoholic steatohepatitis Obesity Other diseases. Semiology Ox-CL oxidative stress Oxidative Stress - immunology oxidised cardiolipin PBS phosphate buffered saline Rodents Serum Albumin - immunology steatosis Studies Womens health
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Zusammenfassung:	Aims: Factors responsible for the progression of non-alcoholic fatty liver disease (NAFLD) to more severe liver injury are poorly understood. In the present study, we investigated the association between immune reactions triggered by oxidative stress and stage of NAFLD. Methods: Titres of IgG against human serum albumin adducted with malondialdehyde (MDA-HSA) or arachidonic acid hydroperoxide (AAHP) and against oxidised cardiolipin (Ox-CL) were measured in 167 NAFLD patients with steatosis only (n = 79), steatohepatitis (n = 74), or steatosis plus cirrhosis (n = 14), and in 59 age and sex matched controls. Results: Circulating IgG against lipid peroxidation products was significantly higher (p
ISSN:	0017-5749 1468-3288 1458-3288
DOI:	10.1136/gut.2004.057968