Diagnosing Lynch syndrome: is the answer in the mouth?

3 Clinically, Lynch syndrome, the most common hereditary disorder predisposing to CRC, is characterised by a greater than 80% lifetime risk of CRC in concert with an excess of several extracolonic cancers namely, endometrial, gastric, pancreatic, small bowel, ovarian, and transitional cell carcinoma of the upper uroepithelial tract (ureter and renal pelvis). [...]diagnosing Lynch syndrome is of considerable importance in order to institute a wide range of cancer surveillance strategies for affected subjects. [...]it is conceivable that the increased vascular complexity may be related to an inheritable trait unrelated to the presence of a DNA MMR gene mutation.