Invasive lobular carcinoma and cytokeratin immunohistochemistry: an audit

Invasive lobular carcinoma and cytokeratin immunohistochemistry: an audit

Small axillary lymph node metastases from an invasive lobular carcinoma of the breast can be notoriously difficult to detect on routine haematoxylin and eosin (H & E) staining. Since August 2001, it has been our departmental policy to carry out immunohistochemistry using a broad spectrum antiker...

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Veröffentlicht in:Journal of clinical pathology 2003-03, Vol.56 (3), p.240-240
Hauptverfasser: Chandler, I P, Oommen, R, Lawson, C W
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers, Tumor - metabolism
Biopsy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma, Lobular - secondary
Correspondence
cytokeratin
Female
Humans
immunohistochemistry
invasive lobular carcinoma
Keratins - metabolism
lymph node status
Lymphatic Metastasis
Lymphatic system
Mastectomy
Neoplasm Proteins - metabolism
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Beschreibung
Zusammenfassung:Small axillary lymph node metastases from an invasive lobular carcinoma of the breast can be notoriously difficult to detect on routine haematoxylin and eosin (H & E) staining. Since August 2001, it has been our departmental policy to carry out immunohistochemistry using a broad spectrum antikeratin antibody (AE1/AE3; Dako Ltd, Ely, Cambridgeshire, UK) to ensure that micrometastases are not missed.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.56.3.240