Discussion: Immunology, cellular pathology, genetics

[...]recent studies from Zambia indicate that PsA improves with the onset of AIDS in human immunodeficiency virus (HIV) positive patients. [...]a dominant role for T cells in PsA has been challenged by a recent randomised study showing that efalizumab, an agent that inhibits T cells, significantly l...

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Veröffentlicht in:	Annals of the rheumatic diseases 2005-03, Vol.64 (suppl 2), p.ii40-ii41
1. Verfasser:	Ritchlin, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Arthritis cellular pathology Cytokines dendritic cell Discussion Genetics HIV HLA Human immunodeficiency virus human leucocyte antigen Immunology Inflammation interleukin Lymphocytes major histocompatibility complex Membranes MHC Morphology Pathogenesis Pathology Population PsA Psoriasis psoriatic arthritis psoriatic arthritis genetics RANKL receptor activator of nuclear factor κB ligand rheumatoid arthritis Studies TNF Tumor necrosis factor-TNF tumour necrosis factor
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Zusammenfassung:	[...]recent studies from Zambia indicate that PsA improves with the onset of AIDS in human immunodeficiency virus (HIV) positive patients. [...]a dominant role for T cells in PsA has been challenged by a recent randomised study showing that efalizumab, an agent that inhibits T cells, significantly lessened psoriasis activity but not joint inflammation in patients with PsA.
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.2004.031559