Massive acute haemolysis in neonates with glucose-6-phosphate dehydrogenase deficiency

Three neonates with glucose-6-phosphate dehydrogenase (G6PD) deficiency are described. All three patients suffered an episode of massive acute haemolysis, in the absence of blood group incompatibilities, infection, or ingestion of oxidising agents known to trigger haemolysis. One patient died, but t...

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Veröffentlicht in:	Archives of disease in childhood. Fetal and neonatal edition 2003-11, Vol.88 (6), p.F534-536
Hauptverfasser:	Dhillon, A S, Darbyshire, P J, Williams, M D, Bissenden, J G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Age anaemia Babies Blood groups Blood platelets Blood Transfusion - methods Case Report DCT Dehydrogenase Dehydrogenases direct Coombs test Diseases in Twins Drug dosages Enzymes Fatal Outcome Female G6PD glucose-6-phosphate dehydrogenase glucose-6-phosphate dehydrogenase deficiency Glucosephosphate Dehydrogenase Deficiency - blood Glucosephosphate Dehydrogenase Deficiency - complications haemoglobin concentration haemolysis Hemolysis - physiology Humans hyperbilirubinaemia Hyperbilirubinemia - etiology Infant, Newborn Infections Ingestion Intubation Light therapy Male Neonates Newborn babies Premature birth Respiratory distress syndrome Surfactants total parenteral nutrition TPN transfusion Ventilation WCC white cell count
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Zusammenfassung:	Three neonates with glucose-6-phosphate dehydrogenase (G6PD) deficiency are described. All three patients suffered an episode of massive acute haemolysis, in the absence of blood group incompatibilities, infection, or ingestion of oxidising agents known to trigger haemolysis. One patient died, but the other two survived after an exchange transfusion. This highlights that G6PD deficiency in the neonatal period may present with severe anaemia in association with hyperbilirubinaemia.
ISSN:	1359-2998 1468-2052
DOI:	10.1136/fn.88.6.F534