NSAIDs, including coxibs, probably do more harm than good, and paracetamol is ineffective for hip OA

NSAIDs, including coxibs, probably do more harm than good, and paracetamol is ineffective for hip OA

2 Two small (n = 50 and n = 60) trials could not be pooled for lack of data. [...]ES calculations are from two trials, where the smallest reported no significant effect, leaving us with a final sample of 387 patients. [...]paracetamol was still recommended given the evidence from clinical experience...

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Veröffentlicht in:Annals of the rheumatic diseases 2005-04, Vol.64 (4), p.655-656
Hauptverfasser: Bjordal, J M, Ljunggren, A E, Klovning, A, Slørdal, L
Format: Artikel
Sprache:eng
Schlagworte:
Acetaminophen - therapeutic use
Analgesics
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Arthritis
Confidence intervals
coxibs
Cyclooxygenase Inhibitors - adverse effects
Humans
Matters Arising
non-steroidal anti-inflammatory drugs
osteoarthritis
Osteoarthritis, Hip - drug therapy
Pain
paracetamol
Practice Guidelines as Topic
Studies
Treatment Outcome
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Zusammenfassung:2 Two small (n = 50 and n = 60) trials could not be pooled for lack of data. [...]ES calculations are from two trials, where the smallest reported no significant effect, leaving us with a final sample of 387 patients. [...]paracetamol was still recommended given the evidence from clinical experience (efficacy, safety, availability, etc) and indirect research evidence from knee OA.
ISSN:0003-4967
1468-2060