A historic issue of the Annals: three papers examine paracetamol in osteoarthritis

Never in the 127 years of paracetamol's existence have so much trial data on OA been reported. Because of the marked placebo effect in pain trials 3 comparison with a placebo is clearly important to determine the true efficacy of any analgesic. [...]it is surprising that despite the widespread use and support of paracetamol in OA until now there have been only four placebo controlled trials of this drug in OA.