Blunted coronary flow reserve in systemic sclerosis: a sign of cardiac involvement in asymptomatic patients

No statistically significant correlation was found between CFR and history of smoking and cholesterol or triglyceride serum levels. [...]no statistically significant correlation was found between CFR and blood pressure values. Patients with lSSc often develop clinical manifestations that are different or less severe than those of patients with dSSc, and the lower CFR found in patients with dSSc seems to support to this observation. [...]the present results confirm previous studies showing that patients with dSSc often have cardiac disease. 9, 10 In conclusion, CFR evaluation is an efficient, non-invasive, and reliable tool for assessing early cardiac disease in SSc.