Serum cytokine levels related to multiple dimensions of fatigue in patients with primary Sjögren’s syndrome

Objective: To test whether serum levels of selected cytokines relate to different dimensions of fatigue in patients with primary Sjögren’s syndrome (pSS). Methods: Sixty female patients with pSS filled out a questionnaire to assess multiple dimensions of fatigue. Scores were compared with values in a population based control group (n = 139). Levels of interleukin (IL)1β, IL2, IL6, IL10, and tumour necrosis factor α were measured in serum with commercial sandwich ELISAs. The relationship between self reported dimensions of fatigue and these serum cytokine levels was determined. Results: Patients with pSS had high scores at all dimensions of fatigue (p