Thrombophilia and thrombosis in systemic lupus erythematosus: a case-control study

The following parameters were determined: protein C, total and free protein S (in 43 patients because five had antivitamin K treatment), antithrombin, activated protein C resistance (APCR), the R506Q mutation of the factor V gene and the G20210A allele of the prothrombin gene, lupus anticoagulant (LAC) (activated partial thromboplastin time, tissue thromboplastin inhibition test, and platelet neutralisation procedure), IgG anticardiolipin antibodies (aCL), IgG and IgM anti-β2-glycoprotein I (anti-β2GPI) antibodies, IgG and IgM antiprothrombin antibodies. [...]we confirm that LAC and aCL >30 GPL units are the main thrombophilic factors associated with thrombosis in SLE.