“Rheumatoid nodules” and lymphoma

Full blood count and differential, erythrocyte sedimentation rate (ESR), C reactive protein (CRP), rheumatoid factor, nuclear antibody profile, thyroid function. Seronegative polyarthritis has been reported as a rheumatological manifestation of B and T cell lymphomas 2 5 6 and arthritis indistinguishable from seronegative rheumatoid arthritis has been described in association with cutaneous T cell lymphoma. 2 The RS3PE syndrome (remitting seronegative symmetrical synovitis with pitting oedema) 7 has been reported in association with non-Hodgkin's lymphoma 8 and other malignant tumours. 9 Although there are features to support this diagnosis in this patient-that is, symmetrical seronegative synovitis with pitting oedema, remitting with a modest dose of corticosteroid; the normal inflammatory indices, nodulosis and panniculitis are not typical.