Dilemmas of low dosage glucocorticoid treatment in rheumatoid arthritis: considerations of timing

[...]the 7.30 am group (B) received their fourth and last dose on the morning of day 4, that is, 24 hours before outcome assessment on day 5. [...]the study is not balanced in the timing of outcome assessments with respect to the alternative LDGT dosing schedules. Patient and physician assessments were made with knowledge of these alternative schedules. [...]caution is needed in interpreting the results of this exploratory study.