Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up

Childhood asthma is generally believed to be a disorder with a good prognosis. However, some asthmatics develop irreversible airway obstruction, probably as a result of airway remodelling. After 21-33 years, 228 adults (aged 13-44 years at baseline) with a history of asthma were re-examined to asses...

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Veröffentlicht in:	Thorax 2003-04, Vol.58 (4), p.322-327
Hauptverfasser:	VONK, J. M, JONGEPIER, H, PANHUYSEN, C. I. M, SCHOUTEN, J. P, BLEECKER, E. R, POSTMA, D. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Airway obstruction (Medicine) Airway Obstruction - etiology Airway Obstruction - physiopathology Asthma Asthma - drug therapy Asthma - physiopathology Asthmatics Biological and medical sciences Bronchodilator Agents - therapeutic use Chronic obstructive pulmonary disease, asthma Cohort Studies Complications and side effects Demographic aspects Female Follow-Up Studies Forced Expiratory Volume - physiology Health aspects Humans Male Medical sciences Middle Aged Pneumology Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Risk Factors
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Beschreibung
Zusammenfassung:	Childhood asthma is generally believed to be a disorder with a good prognosis. However, some asthmatics develop irreversible airway obstruction, probably as a result of airway remodelling. After 21-33 years, 228 adults (aged 13-44 years at baseline) with a history of asthma were re-examined to assess risk factors for the development of irreversible airway obstruction (IAO, forced expiratory volume in 1 second (FEV(1))
ISSN:	0040-6376 1468-3296
DOI:	10.1136/thorax.58.4.322