Cachexia in malaria and heart failure: therapeutic considerations in clinical practice

Cachexia is an independent prognostic marker of survival in many chronic diseases including heart failure and malaria. Morbidity and mortality from malaria is high in most of the third world where it presents a very challenging public health problem. Malaria may present in the UK as fever in the ret...

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Veröffentlicht in:	Postgraduate medical journal 2004-11, Vol.80 (949), p.642-649
Hauptverfasser:	Onwuamaegbu, M E, Henein, M, Coats, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	3-hydroxy-3-methylglutaryl coenzyme A Biological and medical sciences cachexia Cachexia - etiology Cachexia - mortality Cardiomyopathy CHF chronic disease chronic heart failure Chronic illnesses Coma Cytokines Cytokines - antagonists & inhibitors Cytokines - metabolism Disease Drugs General aspects glycosylphosphatidylinositol GPI Heart failure Heart Failure - complications Heart Failure - mortality HMG CoA Human protozoal diseases Humans Infectious diseases interleukin Lipids - blood Malaria Malaria - complications Malaria - immunology Malaria - mortality Medical prognosis Medical sciences MHCI Morbidity Mortality myosin heavy chain isoform Parasites Parasitic diseases Pathogenesis Prognosis Protozoal diseases Public health Review Signal transduction TNF Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF tumour necrosis factor wasting WHO World Health Organisation
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Beschreibung
Zusammenfassung:	Cachexia is an independent prognostic marker of survival in many chronic diseases including heart failure and malaria. Morbidity and mortality from malaria is high in most of the third world where it presents a very challenging public health problem. Malaria may present in the UK as fever in the returning traveller or as fever in overseas visitors. How and why cachexia develops in malaria in a manner similar to the cachexia of chronic heart failure and the treatment strategies that would alter outcomes in both diseases are discussed in this review.
ISSN:	0032-5473 1469-0756
DOI:	10.1136/pgmj.2004.020891