Massive pleural effusion and marked increase of CA-125

The tumour associated CA-125 antigen is widely used in monitoring ovarian carcinoma. In women with a massive pleural effusion and ascites, markedly increased CA-125 levels may lead to an erroneous diagnosis of ovarian cancer. Very high levels of tumour markers may be present in patients with benign...

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Veröffentlicht in:	Postgraduate medical journal 2004-05, Vol.80 (943), p.300-301
Hauptverfasser:	Hussain, S F, Grayez, J, Grigorian, A, Green, J T
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adult Alcohol Anti-Bacterial Agents - therapeutic use Antibiotics Antigens ascites Biological and medical sciences Biomarkers Breast cancer CA-125 CA-125 Antigen - blood Case Report Cellular biology chronic liver disease Diagnosis, Differential Diuretics Diuretics - therapeutic use Drainage Dyspnea - etiology Dyspnea - therapy Fatal Outcome Female General aspects Humans Intensive care Liver cirrhosis Liver diseases Medical sciences Metastasis Ovarian cancer Patients pleural effusion Pleural Effusion - blood Pleural Effusion - etiology Pneumology Respiration, Artificial Respiratory system : syndromes and miscellaneous diseases Tomography Tuberculosis Ultrasonic imaging
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Beschreibung
Zusammenfassung:	The tumour associated CA-125 antigen is widely used in monitoring ovarian carcinoma. In women with a massive pleural effusion and ascites, markedly increased CA-125 levels may lead to an erroneous diagnosis of ovarian cancer. Very high levels of tumour markers may be present in patients with benign pleural effusion, ascites, and chronic liver disease. Raised levels of tumour markers in serum or pleural fluid, in the absence of positive cytology, should be interpreted with caution.
ISSN:	0032-5473 1469-0756
DOI:	10.1136/pgmj.2003.012377